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The YouTuber-turned-boxer pulled no punches when asked about McGregor, who lost his second straight Octagon outing to Poirier last weekend.
The Irishman broke his lower leg in the first round, with the American taking home the victory via doctor's stoppage.
Even though the 'Notorious' suffered a crushing defeat, 'The Problem Child' is still interested in fighting him while slamming his post-fight interview.
The 33-year-old took aim at Poirier's family, with Paul branding his call out as 'evil' and labelled him a 'piece of sh*t'.
On facing the former UFC double champion, the 24-year-old said: "It could happen.
"18 months ago, I said I wanted to fight Conor and people laughed. Now I'm laughing at Conor.
"He needs Jake Paul more than I need him. I would knock the fake teeth out of his mouth. McGregor would not stand a chance."
On McGregor's rant at Jolie, he added: "He's a piece of sh*t. He's sitting there on the ground after losing, talking sh*t to Dustin Poirier's wife. I don't feel bad at all.
"I think he deserves it. I think it's hilarious. I hope he takes a picture with it and posts it on Instagram.
"I just love to see McGregor plummet. He was a meteoric star that's now just taking a nosedive. Before I wanted to fight him and I offered him $50 million, now my offer is $23."
Paul resumes his budding boxing career against former UFC welterweight champion Tyron Woodley next month.
As for McGregor, he's been hit with a medical suspension following his leg break.
Featured Image Credit: PA/Showtime/UFC
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