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The two are slated to meet in the biggest game in club football at the Ataturk Stadium in Istanbul, Turkey.
Istanbul were the scheduled hosts for the 2020 final but because of the COVID-19 pandemic, the final three rounds were played in Lisbon, Portugal, as part of a mini-tournament in August.
The Turkish capital recently entered a lockdown due to infection rates rising but with restrictions set to be eased on May 17, UEFA have confirmed the game will be staged its original location.
There is also optimism that 25,000 fans could be in attendance, including 4,000 for each of this year's finalists.
But many are calling for the final to be relocated to England's national stadium to allow more supporters and easier access to the big game.
Speaking on talkSPORT last night, Andy Goldstein urged UEFA to use "common sense" and have the game played at Wembley.
"This game is scheduled to be played in Turkey, which at the moment is in lockdown," Goldstein said.
"I understand that they will be coming out of lockdown, hopefully, just under two weeks before.
"If UEFA have got any common sense they will move this game to Wembley. Two English sides and in COVID times, this game shouldn't be in a country hit so badly at the moment.
"After the year we've had where everyone has been in lockdown and has been awful, we could play this game at Wembley with 25 per cent capacity and you'd have two English sides at Wembley.
"I know the people at UEFA aren't necessarily listening to this show... some might... but someone at UEFA with a little bit of common sense have got to get this game moved to Wembley so the Man City fan, the Chelsea fan have a chance of going to see this final.
"It has to be played over here."
The United Kingdom's vaccine roll-out and monumental drop in COVID rates means 10,000 fans are to be present at each of the final two games of the Premier League season for clubs.
Wembley has already seen pockets of fans allowed in for the FA Cup semi-final between Leicester and Southampton, as well as the Carabao Cup final where City beat Spurs.
Chelsea and Leicester City have each been given an allocation of around 6,000 tickets for the FA Cup final on 15 May.
In response to talk of Wembley being the better venue for the Champions League final, many have pointed out the stumbling block that the ground will play host to the Championship play-off final on the same day.
But Goldstein's solution is to have that fixture played at Old Trafford.
He added: "Some people have tweeted and texted to say it's the Championship Play-Off final on the same day, move it.
"Move it to Old Trafford. It's not rocket science. Two words... move it. Just move one."
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