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United took the early lead after Davinson Sanchez brought Anthony Martial down inside the box, with Bruno Fernandes firing home from the subsequent spot-kick.
But Spurs quickly turned the tide as Tanguy Ndombele pulled back an equaliser thanks to a horror-show display of defending from United.
Son Heung-min fired Tottenham into the lead in the seventh minute after he latched onto Harry Kane's quickly taken free-kick.
Son then linked up with Kane and the England captain buried Spurs' fourth before half-time.
Jose Mourinho's men would seal a sensational 6-1 win after Serge Aurier and Kane added Spurs' fifth and sixth respectively.
An emotional Evra said after the match: "Alexis Sanchez made a comment when he signed for United, in his first training session he asked his agent to end his contract.
"That's what I am going to ask Sky. I really would like to end my contract with Sky.
"It is my second game, I'm a positive person and I never wanted to talk about United because when you tell the truth it can hurt. I am passionate and I love my club.
"I know you have to have some filter when you talk on TV but it is a shambles."
Evra, who recently launched a scathing attack on United's business in the window, was also furious during the Sky Sports half-time analysis.
Slamming his hand on the desk, the 39-year-old United legend said: "Are you seeing this right now?
"That's why I don't even want to talk about this game because it's a catastrophe what's happening right now.
"My advice to any fan right now is to buy a PlayStation, buy a player like [Jadon] Sancho, even [Lionel] Messi, and start playing. Because it's a disaster.
"You know I've been a player, that's why I don't want to go on about one player, but our defence has been shocking.
"[Eric] Bailly had the chance to play instead of [Victor] Lindelof and he made that mistake. So don't cry when you don't play!
"This is so naive. I'm devastated. And I'm a positive person. But right now I understand the pain of all United fans because no-one right now in this team deserves to play."
Featured Image Credit: Sky Sports
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