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Gareth Southgate's exceptional English crop are already being tipped by many to make history and win the European showpiece - with the visit of Croatia representing a stern test in front of 22,500 optimistic supporters.
Even by the usual pre-tournament standards and national expectation, Southgate's youthful, talented and experienced side will head into the contest hoping to end 55 years of hurt.
According to the bookmakers, the Three Lions are the current second-favourites to win the tournament - and it comes as no surprise, too, especially given the talent among the ranks.
Euro 2020 will conclude on July 11 at Wembley, with the winners walking the famous steps up to the Royal Box to collect the coveted prize.
Will it be England who go on to win it? We can only hope, but first, the Three Lions have to go through a Croatia side that has a plethora of talent among its ranks.
England are 4/6 to win, with Croatia priced at 19/4 to come away with the victory. A draw is priced at 13/5.
Prediction: 2-1 (7/1)
Half-Time/Full-Time: Draw/England (10/3)
England have won 14 of their last 15 home matches and the nation are heavily fancied in this afternoon's match.
With that said, we think England to draw the first half and then come out all guns blazing for the second is a bulletproof bet.
To score and win: Phil Foden (4/1)
The 21-year-old heads into the tournament off the back of winning the PFA Young Player of the Year award after a superb season with Manchester City.
Dubbed the 'Stockport Iniesta', Foden has become one of City's most important players, playing 50 times in all competitions, scoring 16 goals and assisting 10.
It is only a matter of time before he replicates that same form in an England shirt - and what better time than to do it at this year's European Championships.
Request A Bet: Kane, Grealish & Modric 1+ shots on target each (5/1)
And a price of 5/1 is far too juicy to miss on that basis.
Odds are correct at the time of publication and are, as always, subject to change.
Please gamble responsibly. For more information visit: https://www.begambleaware.org.
Felt good to be back out there with the lads :muscle::flag_black: pic.twitter.com/dsUiSR6Dea- Harry Maguire (@HarryMaguire93) June 10, 2021
England's Chelsea and Manchester City contingent, who played in the Champions League final last month, will all be available - with Mason Mount, Reece James and Phil Foden all likely to start the game.
Other than that, England have a fully-fit side to face Croatia and it will be interesting to see who makes Southgate's prestigious starting line-up.
Perisic, of course, scored the 68th-minute equaliser as Croatia came from 1-0 down to beat England 2-1 at the 2018 World Cup semi-final. Yep, it still hurts.
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