The club have already let highly rated youngster Ferran Torres depart for Manchester City in a £23 million deal.
While Francis Coquelin and Dani Parejo have joined Villarreal for a combined total of £11.5 million.
Marca have reported that new boss Javi Gracia has been told any of his players could be sold this summer.
The only player who seems to have a secure future is Jose Gaya, but the defender has been targeted by Barcelona.
Football being played behind closed doors during the pandemic has impacted Valencia heavily, with no fans being allowed at the Mestalla.
The club have also endured one of their worst seasons in recent memory, finishing ninth and 17 points off the top four.
It is the first time the club will miss out on the Champions League in three years and tensions are high between fans and owner Peter Lim.
A run of two wins in 15 matches earlier this year plus fury at a lack of investment saw Albert Celades sacked as manager at the end of June.
Club president Anil Murthy has insisted that they will be able to turn their current predicament around.
"We are bracing ourselves for a difficult season and Valencia will not be the only club affected, he told Straits Times.
"We hired new people and are building a new team. This is very normal in football.
"We are preparing ourselves for the future with a strong and professional medical team so that we can fix the injury situation and have our players fighting fit on the pitch throughout the season.
"We are going to have a complicated season because of Covid-19, so we must be responsible and control costs tightly. What use is a bankrupt club?
"If things go very wrong in the financial aspect due to Covid-19, all clubs will be in trouble. We have to lead through responsible management during the Covid-19 crisis."
Featured Image Credit: PA Images & Valencia
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