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Earlier this month, the two sides met in the Premier League, with new summer signing Romelu Lukaku leading by example as the Blues ran out 3-0 winners to cement themselves as genuine challengers for the title.
Having been handed a particularly tough draw, Dean Smith's men will look to gain revenge for their league defeat and dump the heavily-fancied Blues out of the competition, but can they do it?
Ahead of the game, our tipster Robert Mann takes a look at some of the best bets from Chelsea vs Aston Villa to get your teeth stuck into.
Chelsea are 4/11 to win, with Aston Villa priced at 15/2 to come away with the victory. A draw is priced at 18/5.
Prediction: 2-0 (11/2)
Win to Nil: Chelsea (11/10)
Chelsea have been impressive at the back so far this season, with five clean sheets in six matches across all competitions.
Half-Time/Full-Time: Draw/Chelsea (11/4)
Chelsea have the upper hand in this fixture and are unbeaten in eight of their last nine matches against Aston Villa.
The Blues claimed a 3-0 victory when both teams met at Stamford Bridge earlier this season and we're backing the west London outfit to start slow, but come out in the second half all guns blazing.
Under/Over Goals: Under 2.5 Goals (1/1)
The last four matches involving Villa has produced more than 2.5 goals on three occasions.
However, Lukaku is expected to be rested for Chelsea and his replacement Timo Werner continues to be low on confidence in front of goal - meaning that tonight's affair could be a low-scoring one.
Odds are correct at the time of publication and are, as always, subject to change.
Please gamble responsibly. For more information visit: https://www.begambleaware.org.
What's the team news ahead of tomorrow, boss? ⤵️— Chelsea FC (@ChelseaFC) September 21, 2021
In terms of their line-up, Smith will likely add more experience than they did against Barrow Town last time out in the cup, with the likes of Bertrand Traore and Ollie Watkins expected to play key roles.
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