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Last weekend, Ole Gunnar Solskjaer's dramatically beat the Hammers 2-1, with Cristiano Ronaldo and Jesse Lingard on the scoresheet and David De Gea saving a stoppage-time penalty from spot kick specialist Mark Noble.
Ahead of tonight's game, both teams will be looking at this competition as one they could have a realistic hope of winning.
The Red Devils and the Hammers have met in the competition three times before, with United winning twice and the home team coming out on top in all three matches.
Ahead of the game, our tipster Robert Mann takes a look at some of the best bets from Manchester United vs West Ham United to get your teeth stuck into.
Manchester United are 1/2 to win, with West Ham United priced at 19/4 to come away with the victory. A draw is priced at 3/1.
Prediction: 2-1 (15/2)
Full-Time Result and Both Team To Score: Manchester and Yes (9/4)
Manchester United are the top scorers in the Premier League and the return of five-time Ballon d'Or winner Ronaldo has, undoubtably, strengthened their creative hand.
On the face of it, tonight's game is likely to be a fixture full of goals, however, we reckon United’s cavalier approach and depth of attacking talent should just about see them through.
Anytime Goalscorer: Jesse Lingard (15/8)
Lingard will be pushing for a start against West Ham tonight, with whom he revitalised his career in the second half of last season.
The 28-year-old has had a good start to the season, scoring twice in three Premier League appearances - and even netted against the Hammers just three days ago.
Winning Margin: Manchester United by Exactly 1 Goal (5/2)
West Ham are a completely different club now compared with 18 months ago with David Moyes making them a solid and competitive unit.
We reckon the east London side will run the Red Devils close, but their poor record at Old Trafford - combined with likely changes - means that the home side should just prevail.
Odds are correct at the time of publication and are, as always, subject to change.
Please gamble responsibly. For more information visit: ttps://www.begambleaware.org.
Michail Antonio returns from suspension this week and should slot straight back into the starting line-up as the lone striker, with Winston Reid now the visitors' only injury concern.
"I just want to say thank you and wish you all the best for the future."— West Ham United (@WestHam) September 21, 2021
Reidy on his time at the Club ⬇️
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