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Watford, meanwhile, will know that their aim this season is to survive relegation, and they have already shown early promising signs that they will, having already picked up three points with a triumph over Aston Villa.
Ahead of the game, our tipster Robert Mann takes a look at some of the best bets from Tottenham Hotspur vs Watford to get your teeth stuck into.
Tottenham Hotspur are 2/5 to win, with Watford priced at 7/1 to come away with the victory. A draw is priced at 18/5.
Prediction: 2-0 (11/2)
Half-Time/Full-Time: Tottenham Hotspur/Tottenham Hotspur (11/10)
In 14 head-to-head encounters between the two sides, Tottenham Hotspur hold the clear advantage having won ten, lost one and drawn three.
For that reason, we're backing the north London outfit to lead from the first to last whistle and cement their title challenge.
Win to Nil: Tottenham Hotspur (5/4)
Tottenham will be eager to continue their fine form at home, especially having beaten Pep Guardiola's City in their opening fixture.
Interestingly, Spurs have won to nil in their last five home matches with Watford and, as a result of that, we're backing the same outcome to happen again once more this weekend.
Anytime Goalscorer: Heung-min Son (1/1)
Heung-min Son has had a strong start to the new season after he scored the winning goal in Spurs' opener against City.
The South Korean international has already scored five times against Watford in his career and we're backing him to do so again when he faces a defence that has already conceded four in two games.
Odds are correct at the time of publication and are, as always, subject to change. Please gamble responsibly. For more information visit: https://www.begambleaware.org.
Kane will make his first Premier League start against Watford on Sunday after the England captain announced that he is staying at the club this summer.
In a further setback, goalkeeper Ben Foster will also miss out with a hamstring injury sustained midweek.
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