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Mason Mount scored in the first half on Thursday as Thomas Tuchel's Chelsea side condemned Liverpool to another defeat at Anfield.
Jurgen Klopp's men have since lost 1-0 to Brighton, 4-1 to Manchester City and 2-0 to Everton in the league.
However, Liverpool fans' frustrations continued in the second half of the match after the Reds weren't awarded a penalty for N'Golo Kante's handball.
The Reds languish in seventh place in the table and are a whopping 22 points behind league leaders City.
Jurgen Klopp admitted after the match that the result is a "massive blow" and urged his side to bounce back from the defeat.
The Liverpool boss told Sky Sports: "The individual quality of Mason Mount in that moment made the difference. It was a tight game, intense game. Both teams invested a lot. That is it pretty much.
"They had the goal they scored which was offside. The second half another counterattack, we had more situations around, the great one with Sadio Mane and other situations where we did not score.
"You have to defend differently and we didn't do well there. There are a lot of things out there you have to consider.
"In the end we conceded one goal, we made the mistake there, the other was offside and you can say it was good defending but with all the possession we had you need to have more chances. Everything was really good until the final pass.
"Unfortunately, we cannot say it is only at home. It is not about Anfield or whatever, it is in general, too often.
"In the decisive moments we have to improve. We have to show our quality in these moment and we don't do that often enough.
"I just brought on fresh legs. Mo [Salah] looked like today he suffered a bit, he played a lot of games. I could have taken off Sadio or Bobby, that is all clear but at that moment it looked like Mo.
"[James] Milner we bought on to wake them up a bit and keep them in the game because we needed one situation.
"It is a massive blow. It is not done yet. We have to win football games."
Liverpool will return to Premier League action on Sunday as they host Fulham at Anfield.
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