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The La Liga giants are, by a long stretch, the most successful team in the history of the tournament, having taken home the prestigious trophy a total of 13 times.
With both sides scoring for fun so far this season, the stage is set for what should be a spectacular start to a Champions League group game, but who will come out on top?
Ahead of the game, our tipster Robert Mann takes a look at some of the best bets from Inter Milan vs Real Madrid to get your teeth stuck into.
Inter Milan are 29/20 to win, with Real Madrid priced at 7/4 to come away with the victory. A draw is priced at 5/2.
Prediction: 2-3 (22/1)
Full-Time Result: Real Madrid (5/2)
The sides have met 11 times in European competition and there's nothing between them, with five wins apiece and one draw.
Despite Inter having beaten Real in four of their six competitive meetings on home soil, the Nerazzurri have in fact lost four of their last five games against Los Blancos in a European competition.
First Goalscorer: Karim Benzema (4/1)
If Real Madrid score tonight, then the chances are it will be Karim Benzema who claims it.
The French striker, who was Madrid's top goalscorer last season, has started the season in scintillating form, scoring five goals in four games - including a hat-trick last time out.
Under/Over Goals: Over 3.5 Goals (2/1)
On paper, tonight's clash between these two continental giants should scream goals.
In just four La Liga games, Real Madrid have scored a staggering 13 goals, while Inter Milan have found the back of the net nine times in just three games - and that should tell you all you need to know.
Odds are correct at the time of publication and are, as always, subject to change.
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Simone Inzaghi is unlikely to make too many changes to his starting lineup that played against Sampdoria, so central midfield trio Nicolo Barella, Marcelo Brozovic and Hakan Calhanoglu are all set to keep their places in the side.
Meanwhile, experienced striker Edin Dzeko is expected to lead the line in attack alongside Argentina international Lautaro Martinez, though the latter's compatriot Joaquin Correa will also be pushing for a place in the starting line-up.
Benzema, who needs just one more goal to move ahead of club legend Raul into outright fourth place on the all-time list of goalscorers in Champions League history, is expected to lead the line in attack and could be joined once again by wingers Eden Hazard and Vinicius Junior.