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After improved results as of late, City will head into tonight's game with a spring in their step and they will hope they can overcome their German opponents with ease.
Having just been thrashed 4-1 by Bayern Munich, Leipzig will be wary that more misery will come at the hands of the reigning Premier League champions, but can they cause an upset?
Ahead of the game, our tipster Robert Mann takes a look at some of the best bets from Manchester City vs RB Leipzig to get your teeth stuck into.
Manchester City are 3/10 to win, with RB Leipzig priced at 17/2 to come away with the victory. A draw is priced at 17/4.
Prediction: 2-1 (7/1)
Half-Time/Full-Time: Manchester City/Manchester City (4/5)
In terms of the Champions League, Guardiola’s men are unbeaten in their last 17 games in the group stages and, as a result of just that, we reckon they should have too much quality for their German opponents.
First Goalscorer: Riyad Mahrez (9/2)
Without a recognised striker among their ranks, City often turn to the likes of Mahrez for goals and his form suggests he can be trusted in Europe's most competitive competition.
Win to Nil: Manchester City (6/5)
City’s three clean sheets on the spin mean they will be confident of shutting out Leipzig and we reckon it should be a routine victory for the blue side of Manchester.
On the face of it, Leipzig have failed to score in their last two games on the road, while in the Champions League, they have not scored in three of their previous four on the road.
Odds are correct at the time of publication and are, as always, subject to change.
Please gamble responsibly. For more information visit: https://www.begambleaware.org.
Defensive stalwart Marcelo Saracchi continues to rehabilitate following a cruciate ligament tear, while Marcel Halstenberg is nursing an ankle problem.
Former City left-back Angelino was fit enough to play 58 minutes against Bayern after shaking off a muscular issue and Lukas Klostermann is an option for change on the opposite side over Nordi Mukiele.
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