Mo Salah had to be escorted off the pitch by security after missing a crucial spot-kick as Egypt failed to make the World Cup in Qatar.
After winning the first leg 1-0, the Pharaohs lost by the same scoreline in normal time of the second fixture courtesy of an early own goal from Hamdi Fathi.
In a repeat of the Africa Cup of Nations final last month, the play-off went all the way to penalties and it was a case of deja vu as Sadio Mane was the hero in the shoot-out yet again.
This time, however, Salah uncharacteristically blazed his spot-kick over the bar after having laser pens shined on him as he stepped up.
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And it wasn't the only disgraceful treatment the Liverpool star was subjected to at Stade Me Abdoulaye Wade from the home supporters.
Many invaded the pitch to celebrate reaching the World Cup later this year. Some who had made their way onto the turf tried to get to Salah, with slew of security guards needed to come to his protection and walk him down the tunnel.
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But then as they did, Senegal fans in the stands pelted Salah with missiles in shocking, unsavoury scenes.
Both sides missed their first four penalties in the shoot-out but Senegal ended up winning 3-1 after Mane held his nerve from 12 yards when the pressure was on.
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As well as Senegal, Cameroon, Morocco, Tunisia and Ghana all qualified for the latest showpiece, with Nigeria and Algeria both missing out after losing their World Cup play-off.
The group stage draw will take place on Friday.
Topics: Mohamed Salah, Egypt, Senegal, Sadio Mane, Football World Cup, Liverpool
Josh Lawless