Manchester United host Leicester City at Old Trafford on Tuesday night and will look to delay Manchester City's title celebrations for the second time in two days.
In contrast, the Champions League-chasing Foxes will be doing all they can to return to winning way after a surprise 4-2 home defeat by Newcastle United on Friday evening.
A win at Aston Villa was the start of a run of three games in five days for Ole Gunnar Solskjaer and co, culminating with the rescheduled visit of Liverpool on Thursday.
Meanwhile, for Leicester, their shock loss to Newcastle wasn't ideal, but West Ham's own defeat to Everton have given the Foxes some much-needed breathing space in their bid to finish fourth or higher.
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Leicester City are unbeaten this season against Solksjaer's men, with a 2-2 draw at the King Power Stadium on Boxing Day, followed by a 3-1 triumph in the FA Cup.
But Manchester United have won four in a row in this fixture before that - in a 12-game unbeaten run against the Foxes.
Taking that into account and the fact that United have not lost in their last 11 matches at Old Trafford, the Red Devils have what it takes to extend that record this evening.
Manchester United vs Leicester City betting tips
Manchester United are 6/4 to win, with Leicester City priced at 2/1 to come away with the victory. A draw is priced at 23/10.
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Prediction: 2-1 10/1
Over 2.5 goals: Evens
Both sets of players are sure to be feeling the effects of a demanding campaign, and scorelines have reflected the diminishing importance of home advantage.
United's last six games in all competitions at Old Trafford have produced 20 goals, the same tally as Leicester's last six in all competitions.
Both this season's meetings between the sides have produced four goals, United drawing 2-2 in the reverse league fixture and Leicester winning an FA Cup quarter-final 3-1.
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With that said, expect goals to rain during tonight's game as it has done in previous fixtures - three sounds like the magic number.
Manchester United to win: 6/4
Manchester United may need a miracle to get their hands on the Premier League trophy, but they are doing all they can to delay their neighbours from celebrating another title success.
The Red Devils are ten points behind City with a game in hand and could close the gap to four points by beating Leicester on Tuesday and Liverpool on Thursday - their third and fourth matches in an eight-day spell.
While United are flying high, Leicester are showing signs of cracking, having slipped to fourth after drawing at Southampton and losing to Newcastle.
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Analysing the head-to-head record, it is hard to overlook United in the betting.
They are unbeaten in their last 12 Premier League matches against Leicester, their most recent defeat coming in 2014 - we expect them to win with ease this evening.
To score first: Mason Greenwood 7/1
Mason Greenwood has had to bide his time this season, with the Englishman behind the likes of Marcus Rashford, Anthony Martial and Edinson Cavani in the pecking order.
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The 19-year-old started Sunday's 3-1 win over Aston Villa, and he rewarded Solskjaer for his inclusion with a goal.
Greenwood has scored seven goals in his last ten appearances - and looks set to add more to his flourishing record.
The youngster also knows how to score against this evening's opponents, having found the net in the 3-1 defeat in the FA Cup in March.
Odds are correct at the time of publication and are, as always, subject to change.
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Manchester United vs Leicester City head-to-head results
Manchester United and Leicester City have met a total of 64 times in the Premier League with United coming out on top with the most victories.
Manchester United wins: 43
Leicester City wins: 6
Draws: 15
Last meeting: Leicester City 2-2 Manchester United (26/12/2020)
Manchester United team news
Ex-Leicester defender Harry Maguire looks set to miss his first Premier League match since joining United after injuring his ankle against Aston Villa on Sunday.
Anthony Martial and Phil Jones remain sidelined for the hosts, while Daniel James has missed recent matches.
Leicester City team news
Leicester are likely to be without Jonny Evans for the trip to Old Trafford.
The former United defender limped out of the warm-up ahead of Friday's 4-2 defeat to Newcastle and has been playing with a heel problem.
Harvey Barnes and James Justin are out for Brendan Rodgers' side while Wes Morgan is not expected to feature again this season.
Featured Image Credit:Topics: Leicester City, Manchester United