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England are on a run of five straight victories - with only one goal conceded - while Romania have lost their last three in a row.
The Three Lions come into this game on the back of a 1-0 win over Franco Foda's Austria in an international friendly game held at the Riverside on Tuesday night.
A second-half goal from young attacker Bukayo Saka sealed the deal for Southgate's youthful England side.
Celebrating in front of the fans again :heart_eyes:- England (@England) June 4, 2021
Go pitchside for the #ThreeLions' win against Austria:
Romania, on the other hand, lost 2-1 to Georgia at the Ilie Oana Stadium in an international friendly game.
England have an incredibly strong side available going into this game and will almost certainly be wanting to make their mark at the Euros.
England are 1/4 to win, with Romania priced at 9/1 to come away with the victory. A draw is priced at 5/1.
Prediction: 2-0 5/1
Half-Time/Full-Time: Draw/England 11/4
The Three Lions have a poor record against Romania, however, the last time they played was a little over 21 years ago.
But we expect England to put a stamp of authority during Sunday's game, as Southgate calls upon more of his first 11 regulars.
The Three Lions are quite slow starters and that was even more evident against Austria on Tuesday night.
With that said, we think England to draw the first half and then come out all guns blazing for the second is a bulletproof bet.
To score first: Harry Kane 21/10
With the Euros just around the corner, England will be heading into this game hungry for goals - and there is no better man to do so than star striker Harry Kane.
Having already scored 34 times for his country, the wantaway Spurs forward should get a number of chances against a defensively poor Romania team.
Kane to score first sounds like a given, right?
Player shots on target: Harry Kane 4+ shots on target 7/2
Harry Kane is unlikely to play the full 90 minutes on Sunday, with the opening match of the Euros getting closer - but that doesn't mean he won't have a big part to play.
England's opposition on Sunday have kept just one clean sheet in their last 15 international matches.
Kane will surely be fancying his chances to add to his England goal tally here.
Four or more shots on target for the hitman sounds like another given.
Odds are correct at the time of publication and are, as always, subject to change.
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2 June FRI England 1 Austria 0 W
31 March WCQ England 2 Poland 1 W
28 March WCQ Albania 0 England 2 W
25 March WCQ England 5 San Marino 0 W
18 November NL England 4 Iceland 0 W
2 June FRI Romania 1 Georgia 2
31 March WCQ Armenia 3 Romania 2 L
28 March WCQ Romania 0 Germany 1 L
25 March WCQ Romania 3 North Macedonia 2 W
18 November UNL Northern Ireland 1 Romania 1 D
England boast a star-studded squad, although there are some fitness issues.
Meanwhile, Romania manager Mirel Radoi has called up Sassuolo centre-back Vlad Chiriches, Slavia Prague forward Nicolae Stanciu, Cagliari midfielder Razvan Marin and Rangers attacker Ianis Hagi.
Elsewhere, star forward Florin Tanase is suspended.
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