The 24-year-old YouTuber-turned-boxer was initially slated to fight former Love Island star Tommy Fury before the Brit pulled out due to a bacterial chest infection and broken rib.
Woodley, who took Paul the full distance in their initial clash in August, stepped up on short notice to replace Fury and set up a rematch with the Problem Child.
With over 20,000 fans packed into the Amalie Arena, an uneventful first round saw both fighters met with boos after repeated clinches.
Paul and Woodley exchanged blows in the second round, but both boxers were warned again by the referee over repeated clinches amid growing boos from fans.
However, the clash took a dramatic twist going into the third after Paul received a nasty cut to the forehead following an accidental headbutt from Woodley.
Woodley landed a solid one-two to Paul during the third round, with Paul appearing to be bothered by the blood gushing from his cut.
The 39-year-old former UFC star was warned by the referee in the fourth round after he planted Paul to the canvas with a WWE-esque body slam.
Woodley was unable to build serious momentum and managed to headbutt Paul for the second time in the fifth round of their rematch in Tampa, Florida.
Paul fought back going into the sixth round and finally made the major breakthrough with a devastating right-handed shot on Woodley.
The referee immediately waved off the clash, with Paul extending his unbeaten professional boxing record to 5-0.
Paul has now stopped all of his opponents to date, with his hard-fought victory over Woodley effectively ending their rivalry inside the squared circle.
Featured Image Credit: Showtime Boxing/Twitter
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