Erik ten Hag's men will be looking to get back to winning ways in the Premier League against Everton.
Last time out, Manchester United were bested by Manchester City in a 6-3 defeat at the Etihad stadium, with Erling Haaland, Phil Foden, Anthony Martial and Antony among the goals.
United most recently defeated Omonia in the Europa League with a 3-2 away victory.
Global kick-off times
United Kingdom
19:00 BST
United Arab Emirates
22:00 GST
United States of America
Eastern time: 14:00 EDT
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Pacific time: 11:00 PST
Indian subcontinent
23:00 IST
TV listings
In the UK, the crunch clash will be shown live on BT Sport 1, with build-up starting at 17:15 BST.
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The match can be live-streamed from the BT Sport app, which requires a subscription to use.
UAE viewers will be able to view the fixture on beIN Sports Connect.
The USA will broadcast the game on USA Network, with those in the Indian subcontinent able to tune in on JioTV.
Highlights of the game will be available on the BT Sport and Man Utd YouTube channels post-match.
Topics: Manchester United, Everton, Premier League
Dylan Penketh