It is believed that Kane, 27, will tell Spurs he wants to leave if they fail to qualify for the Champions League next season.
The England star is growing frustrated at his side's failure to compete for major trophies.
He is set to make a decision on his next move after the European Championships this summer, with Man United reportedly interested in bringing him to Old Trafford.
And Berbatov, who himself swapped Spurs for Man United in 2008, has revealed he would not be surprised if Kane opted to switch Premier League allegiances during the summer transfer window.
He told Betfair: "It would be sad if he looks back in his career and has not been a Premier League champion at some point as he is one of the best strikers in the world.
"It's a tough decision as he is in a great environment, with a great stadium, training ground and more.
"The only thing missing for him is trophies."
The Bulgarian, who won two league titles during his time at Man United, added: "I can see why Kane would want to move if they don't make the Champions League and if they don't win the League Cup.
"I would not be surprised as of course he wants to play Champions League football. It depends on how Spurs finish the season."
Berbatov continued: "I was Harry Kane at Tottenham once.
"I was in this position with the same decision and at the same club. There will be big thoughts going through his head.
"If he moves, he will be disappointing lots of Spurs fans. Some will turn against him, it is how it is in football.
"Fans take it personally and think that you are leaving, they feel that you've betrayed the club.
"My situation was similar, but also slightly different.
"I wanted to go to the biggest club to win trophies and that was Manchester United.
"When I heard there was a chance to go there, I did not hesitate."
Will Kane leave Spurs in the summer? Watch this space.
Featured Image Credit: YouTube/PA
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