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The goalkeeper is 'fuming' after a string of broken promises at Old Trafford and aired his frustrations on Tuesday.
Henderson says he was promised the no.1 jersey ahead of David de Gea after Euro 2020, but he only made three appearances in all competitions last season.
He then claimed United 'wasted' 12 months of his career and described himself as a 'caged animal', before going on to say he wanted to face his parent club.
Jamie O'Hara believes it's ended any hopes of the 25-year-old being a regular for the Red Devils.
He told talkSPORT: "It seems pretty shocking. He’s obviously got his back up. He’s gone back in thinking he will be involved.
"Let’s be honest, David de Gea was superb last season for Man United. He’s the No.1 ‘keeper and one of the best in the world.
"Dean Henderson has to accept he is going to be a bit part player when David de Gea is there.
"I don’t think he will play for Man United again. That’s it now. When you do an interview like that, you come out and slate your parent club it never goes down well with the fans with the coaching staff."
Henderson also said he didn't speak with new manager Erik ten Hag before making a move.
The England international believes ten Hag would want to keep him once he saw him in action.
O'Hara continued: "The new manager will come in and look at it and go 'it’s time to move on'. Maybe he has done that interview because in the long run, he probably will want to move on.
"He’s a top ‘keeper, by the way. He is probably too good to be sat on the bench, but it is Manchester United.
"You don’t come out and slate Manchester United if you are part of the football club. Let’s be honest, the only way Dean Henderson is going to go to at United is down.
"Sometimes players say things in the heat of the moment when they are angry. We’ve all done it and lived to regret that moment."
Henderson is one 12 signings made by Forest following their promotion to the Premier League.
Joining Henderson at the City Ground is Giulian Biancone, Omar Richards, Lewis O'Brien, Harry Toffolo, Brandon Aguilera, Orel Mangala, Neco Williams, Wayne Hennessey, Taiwo Awoniyi, Moussa Niakhate and former United teammate Jesse Lingard.
Steve Cooper's side kick off their first top-flight season in 22 years against Newcastle United on August 6.