Arne Slot has been hit with a disastrous triple injury blow ahead of Liverpool's huge Premier League showdown against Everton.
Slot's Liverpool players are currently away on international duty following their Carabao Cup final defeat to Newcastle United last weekend.
Newcastle beat Liverpool 2-1 at Wembley Stadium to secure their first major piece of silverware in 70 years.
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The cup final loss came just days after the Reds were dumped out of the Champions League following their 4-1 penalty shootout defeat to Paris Saint-Germain.
Liverpool resume their stunning Premier League campaign once the international break is over.
Slot's side host cross-town rivals Everton, having met for the first time this season last February, with the Goodison Park clash ending 2-2.
Ahead of welcoming David Moyes' team to Anfield on April 2, Slot could be without three key players.
Alisson had to be substituted with a suspected concussion in Brazil's 2-1 win over Colombia on Friday.
The Brazilian goalkeeper, who didn't start against Newcastle in the Carabao Cup final, was forced off in the 78th minute after colliding with Davinson Sanchez.
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Ibrahima Konate's international outing was also cut short. He started France's Nations League tie against Croatia but was hauled off at the break after picking up a 'knock'.
Konate started Liverpool's cup final defeat last weekend before being replaced.
Ryan Gravenberch rounds off Liverpool's injury woes as he pulled out out of the Netherlands squad.
He suffered an injury against Newcastle as his situation has not improved while he has been away.
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In a statement released by Liverpool, Gravenberch will be assessed upon returning to his club.
A statement read: "Ryan Gravenberch has departed the Netherlands camp and will not be involved in their fixtures this week.
"The Liverpool midfielder had linked up with his country, alongside Cody Gakpo and Virgil van Dijk, for a UEFA Nations League double-header versus Spain on Thursday and Sunday.
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"However, the Dutch announced on Wednesday evening that Gravenberch has now withdrawn from duty due to a fitness issue.
"The 22-year-old will be assessed upon his return to Merseyside, with the Reds back in action when they host Everton in the Premier League on April 2."
Nasir Jabbar