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But one of the striker's greatest afternoons with the Red Devils was undoubtedly his hat-trick against old rivals Liverpool.
It's the biggest fixture in English football and, with both teams eyeing the title, Sunday's meeting at Anfield takes on even more significance.
United fans would happily settle for a similar outcome to the 3-2 win over Liverpool at Old Trafford in September 2010.
Berbatov rightly took the headlines that day.
Having netted four times in United's opening five games of the 2010/11 season, he was at his brilliant best in the clash with the Reds.
The Bulgarian scored either side of the interval - the second a stunning overhead kick - to put Sir Alex Ferguson's side in complete control against a subdued Liverpool.
One touch on the knee and bang.- The Man Utd Way (@TheManUtdWay) February 21, 2019
Dimitar Berbatov's overhead kick against Liverpool is up there with one of my favourites. There's nothing that man couldn't do! pic.twitter.com/7Jex2DcSrc
Liverpool were thrown a lifeline as Steven Gerrard scored twice in six minutes midway through the second half.
But Berbatov had the final say, bagging the winner with a towering header six minutes from time.
"When I was growing up in Bulgaria, I had no knowledge of the rivalry between United and Liverpool," Berbatov told the Red Devils' official website last year.
"When you become part of United, now you have no choice. You have to think about that game, that rivalry. Liverpool was the team we were trying to surpass on league titles when I got to Old Trafford. They had 18, we had 17.
"At the start of 2010/11, they came to Old Trafford. I knew that it was going to be a good day. That whole season, I had a good feeling.
"The second goal, people ask me about it all the time. How you react in those split seconds shows the world how you see football.
"In that moment, everything was perfect. The control of the ball, the bicycle, then the ball hitting the bar and going in the goal for more dramatic effect.
"Afterwards, I found out that it was the first hat-trick for United against Liverpool in something like 65 years.
"It makes me smile because it makes it even more special. A hat-trick, at Old Trafford, against Liverpool, to win the game. Perfect."
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