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The Gunners, on the other hand, have been marooned in mid-table for much of the campaign, although back-to-back league wins over Newcastle United and West Bromwich Albion mean they still have an outside chance of securing European football for next season.
And in tonight's game, Chelsea's attacking players will be aiming to earn themselves a place in this weekend's FA Cup final line-up.
Arsenal, meanwhile, make the short trip across the city after relegating West Brom with a 3-1 win on Sunday, but that victory will have done little to lift the gloom in north London.
Chelsea are 4/6 to win, with Arsenal priced at 4/1 to come away with the victory. A draw is priced at 29/10.
Prediction: 2-0 15/2
Arsenal won the reverse fixture 3-1 and could complete the league double over Chelsea for the first time since 2003-04.
However, Chelsea are currently in imperious form under Thomas Tuchel and have an FA Cup and Champions League final to prepare for.
With that said, the Blues should take no prisoners this evening and Mikel Arteta will almost certainly be dreading just that.
Half-Time/Full-Time: Chelsea/Chelsea 2/1
Despite being the home side for this fixture, Chelsea will still have to be at their very best if they intend on taking all three points.
The hosts have won four of their last six matches in all competitions and claim the title of form favourites against Arsenal.
We predict Chelsea to make all and lead from start to finish, adding to Arsenal's woes.
To be carded: Jorginho 14/5
Midfield maestro Jorginho looks like he could be prone to a foul or two in this evening's game - as we expect a lot of the ball will be played in the middle of the park.
The ill-disciplined Italian has already totted up six cards this term and he looks overpriced to have his name taken on Wednesday night when faced with what is a fluid and youthful Arsenal frontline.
To score anytime: Kai Havertz 2/1
Kai Havertz has taken time to settle at Chelsea since his arrival from Bayern Leverkusen last summer, but there are signs are that the Germany midfielder is starting to feel at home in his new surroundings.
The 21-year-old's all-round game certainly seems to be improving and he looks to have become accustomed to Tuchel's rotation policy.
It seems likely that he will return to Chelsea's starting 11 after being an unused substitute against Manchester City at the weekend and he looks good value to score during 90 minutes.
Chelsea and Arsenal have met a total of 202 times in the Premier League with Chelsea narrowly coming out on top with the most victories.
Chelsea wins: 65
Arsenal wins: 58
Last meeting: Arsenal 3-1 Chelsea (26/12/2020)
Elsewhere, Andreas Christensen limped off after landing awkwardly during Chelsea's 2-1 win against City last Saturday.
The centre-back will not be fit for tonight's game against Arsenal and is facing a race to make the cup final against Leicester - but Tuchel is adamant he will be back in time for the Champions League showdown with City at the end of the month.
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