Manchester City host Brentford in the early Saturday lunchtime kick-off, with the clash at the Etihad Stadium being their final match before the break for the 2022 FIFA World Cup.
The Premier League champions will certainly have their eyes set on the top-flight's top spot over Christmas, but require a number of factors this weekend for that to happen.
Firstly, Manchester City will have to move past a Brentford side that have failed to record a single win across competitions since mid-October.
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The visitors to the Etihad Stadium this weekend come in to the game off the back of a shock Carabao Cup third round exit at the hands of Gillingham in midweek.
Pep Guardiola and his players will also require a favour from Wolves in the evening kick-off on Saturday, as the Midlands club host Arsenal - who currently lead the Premier League by two points.
Manchester City come in to their final game of the first-half of the season off the back of a Carabao Cup third round win, as they moved past Chelsea on Wednesday night via goals from Riyad Mahrez and Julian Alvarez.
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For the hosts, Kyle Walker will remain absent through injury, as he continues to recover from groin surgery in time to play some part in England's World Cup campaign in Qatar later this month.
Erling Haaland is somewhat a doubt in regards to whether he can start this weekend's match, after the Norwegian continues to fully recover from a foot problem.
Joao Cancelo also returns for the hosts, as he completed his one-match suspension during the win over Graham Potter's side in the cup.
Ahead of kick-off in the Premier League, here is how both Manchester City and Brentford line-up!
Manchester City
Starting XI: Ederson; Stones, Akanji, Laporte, Cancelo; De Bruyne, Rodri, Gundogan; Bernardo, Haaland, Foden
Substitutes: Ortega Moreno, Dias, Phillips, Grealish, Alvarez, Gomez, Mahrez, Palmer, Lewis
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Brentford
Starting XI: Raya; Rasmussen, Zanka, Mee, Pinnock, Henry; Onyeka, Janelt, Jensen; Mbeumo, Toney
Substitutes: Cox, Yarmolyuk, Canos, Crama, Dasilva, Lewis-Potter, Ghoddos, Norgaard, Wissa
Topics: Manchester City, Brentford, Premier League, Football, Pep Guardiola
Freddie Pye