The pair have been embroiled in a bitter feud for months and were set to do battle in Miami a week on Saturday.
However, YouTuber KEEMSTAR has claimed two separate sources have told him Fury is ready to drop out of the fight on short notice.
Former UFC star Tyron Woodley, who Paul defeated back in August, is set to step in as a sensational last-minute replacement.
Tommy Fury drops out of Dec 18th fight with Jake Paul : 2 Sources.
Tyron Woodley looking to fill in the spot. pic.twitter.com/Nh25Y2IlYE
- KEEM (@KEEMSTAR) December 6, 2021
I've had it confirmed the Jake Paul vs Tommy Fury fight is off, folks.- Chisanga Malata (@Chisanga_Malata) December 6, 2021
Fury is out with an injury. pic.twitter.com/D9a6HSckln
SunSport have also claimed the fight is in 'major doubt' due to an injury.
Promoter Frank Warren recently admitted Fury has suffered from a cold during his preparations.
He explained: "Tommy had a little bit of a cold but hopefully he is going to be okay.
"We are up in Morecambe [on Wednesday] so hopefully we will know more then, but he is up for it and he wants to fight.
"He can't wait for the fight and I know certainly from Jake's perspective he can't wait for the fight."
The 22-year-old has been training in Morecambe with brother Tyson and father John, with the latter stealing the limelight in a press conference last month.
:bangbang: The Jake Paul vs Tommy Fury press conference descends into chaos as John Fury goes at it with Jake exchanging wild insults while Tommy and Tyson watch...
[:projector:️ @BTSportBoxing] pic.twitter.com/mXr2nBBKs8
- Michael Benson (@MichaelBensonn) November 24, 2021
John traded verbal insults with Paul via video conference and it got so nasty, BT Sport had to issue an apology.
He claimed his son would 'bend' Paul's girlfriend, Julia Rose, over and do her 'like a dog' after achieving victory and it mortified everyone.
Paul looked flabbergasted on the TV screen while Tommy looked on in amazement, shocked his dad said that right next to him.