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Poirier stopped McGregor - in his first fight in a year - in the second round of UFC 257's main event at Fight Island.
McGregor and Poirier had met for the first time in September 2014 as featherweights. Back then McGregor won by knockout in just 106 seconds.
After evening the overall scores, there is talk of a third bout between the two.
However, UFC president White has doubts as to whether McGregor has the motivation to continue in the MMA game.
"Look, there's two ways this goes - hungrier or I'm done. He's got the money," White said in the post-fight press conference.
"This is like Rocky III, when you get offered a 300-foot yacht. It's tough to be a savage when he's living like he is.
"When he was a young kid, he was hungry. Now he's got everything he ever wanted so I don't know, it goes this way or that way."
Thanks for the support everyone! Was not my night/morning in there but a great contest to improve on. I'm excited at the blockbuster trilogy I now have on my hands. Dustin is a hell of a competitor and I look forward to going again. God bless us all, happy Sunday :heart:
- Conor McGregor (@TheNotoriousMMA) January 24, 2021
McGregor had come out of retirement for a third time to face Poirier. And he doesn't appear ready to throw in the towel just yet.
"I'll keep my eyes on the prize," said the Notorious. "Don't write me off yet, I'll make my adjustments and keep moving.
"I'll go back, get healthy and I'll re-prepare. I've got to a great place in my body physically and I'll continue to grow that.
"Dustin had a hell of a fight. I felt alright in the second round, felt better than him in the clinch but too little too late - my leg was compromised, and I didn't adjust.
"Fair play to Dustin, I'm happy for him. I'm happy to compete in these challenging times. I don't know where I am at the minute. He fought a hell of a fight but what can you do."
#UFC257 - #InAbuDhabi#UFCFightIsland @ufc @UFCEurope
#McGregorPoirier
Sadly @TheNotoriousMMA #ConorMcGregor lost the #UFC fight outside of the ring; showing @DustinPoirier to much respect, no hunger to fight; with an inadequate training camp... pic.twitter.com/LicJlvUNFz
- Pierce O' Cinnéide :flag_ie: (@PierceOCinneide) January 24, 2021
Floyd Mayweather mocked McGregor after the fight, writing on his Instagram account: "Just know that bum will never be me or be on my level.
"I'm just built different, my mindset is on another planet, my skills are second to none, I'm a natural-born winner, and yes, I talk a lot of trash, but every time I back it up! This is what they hate.
"The world knows Con Artist McLoser can steal everything from me and be loved but I'm hated."
Featured Image Credit: TheMacLife & Conor McGregor/Instagram
Topics: Conor Mcgregor, Dustin Poirier, Dana White