Spurs manager Mauricio Pochettino has revealed that he regrets leaving Juan Foyth out of his Champions League squad.
The Argentine is ineligible as he was not included in the North London sides squad submitted at the beginning of the competition.
The 20-year-old has impressed at the back recently but will be unavailable tonight for Spurs as they know they must beat Inter Milan for any chance of progression to the knock-out stages.
Tottenham host the Italian side at Wembley and Pochettino admits that is it painful not having Foyth available for selection.
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"That is so painful," the Argentine said when questioned about the centre-backs ineligibility.
"It's a mistake we made that at this level of football we cannot repeat again. We need to find a solution.
"At the start of the season I was disappointed because the squad was so big. People say, 'You were the only club not to sign any players.'
"But to sign another player means to put another off the Champions League list. We needed an English player, but it was impossible.
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"It is painful to have a player off the list, but we will finish (the group stage) soon and hope that in March we can do a new list and we can include him on it.
"When you make that decision (of who to leave out), you cannot guess what is going to happen."
Spurs are also missing centre-half Davinson Sanchez, therefore, fit again Jan Vertonghen should start alongside fellow Belgian Toby Alderweireld at the back, while Kieran Trippier is also still injured, although Danny Rose could return for the first time since September.
Inter came from a goal behind late on in the reverse leg to win 2-1 at the San Siro, however, Tottenham are favourites for the three points this time at 4/6.
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A tempting 4/1 says the Italians win at Wembley and secure qualification, while a draw is 3/1.
Tottenham's Harry Kane and Inter's Mauro Icardi are, without doubt, the men to watch, Kane has four goals in his last four Champions League clashes and Icardi has three so far this campaign.
The World Cup Golden Boot winner is 13/5 to open the scoring tonight, while the Argentine is 5/1 to fire his side into the lead.
Both forwards to score and four plus corners a side is a juicy 11/1 with Paddy Power.
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