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Both Rangers and Lyon last faced each other in the 2007/08 Champions League group stages and, on both occasions, the away side won 3-0.
With Ibrox at full capacity for a high-profile European fixture for the first time in almost 18 months, tonight's affair is set to be a momentous occasion for Rangers fans, but will they come out on top?
Ahead of the game, our tipster Robert Mann takes a look at some of the best bets from Rangers vs Lyon to get your teeth stuck into.
Rangers are 15/8 to win, with Lyon priced at 11/8 to come away with the victory. A draw is priced at 12/5.
Prediction: 0-2 (11/1)
Match Result: Lyon (11/8)
Rangers are currently unbeaten in their last ten Europa League group-stage matches and have also lost only four of their last 27 European games.
However, even though Rangers will have close to 50,000 roaring supporters behind them at Ibrox, we feel that the attacking threat that Lyon possess will cause the hosts a number of problems.
Under/Over Goals: Under 2.5 Goals (10/11)
Given the usually cautious nature of a European group stages, taking on goals makes plenty of sense in this opening fixture.
Interestingly, Rangers’ attacking intensity has dropped off this season, with the Gers averaging just 1.5 goals per match, as opposed to their 2.42 average of last season in the Scottish Premier League.
Player To Be Carded: Glen Kamara (9/2)
Rangers' midfield maestro Glen Kamara is perhaps worth a speculative punt, especially at attractive odds of 9/2, to go into the referee's book.
The Finland international is yet to see yellow this season, however, he was cautioned in no fewer than three ties at Ibrox last term and the price looks slightly bit too big to us, especially given the European pedigree of the opposition..
Odds are correct at the time of publication and are, as always, subject to change.
Please gamble responsibly. For more information visit: https://www.begambleaware.org.
Defensive stalwart Conor Goldson will be available for selection on Thursday after completing a spell in self-isolation.
Winger Ianis Hagi is also ruled out after testing positive for COVID-19, while midfielder Ryan Jack continues to recover from a calf injury.
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