Angel Di Maria helped fire PSG into the lead against Brest after his corner kick took a huge deflection off an opposition player.
The defending French champions travelled to the Stade Francis-Le Ble on Sunday for their crucial Ligue 1 clash.
PSG trail Lille in the Ligue 1 title race as their French rivals can secure the trophy if they beat Angers.
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Mauricio Pochettino's men failed to take the early lead after Neymar missed from the spot-kick with a dreadful effort.
Neymar performed a staggered run-up and Brest 'keeper Gautier Larsonneur remained rooted to the spot as the PSG superstar's effort rolled wide of the right post.
However, PSG broke the deadlock ahead of half-time as Di Maria stepped up for a corner kick.
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The former Real Madrid star's corner took a massive deflection off Brest midfielder Romain Faivre as it looped into the air and over a helpless Larsonneur.
PSG took a 1-0 lead into half-time at the Stade Francis-Le Ble.
Lille, meanwhile, edge closer to the Ligue 1 title as they lead Angers 2-0 at the Stade Raymond Kopa.
Full-time result: Kylian Mbappe scored in the second half as Paris Saint-Germain defeated Brest 2-0 at the Stade Francis-Le Ble.
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Featured Image Credit: BT Sport/Twitter
Topics: Paris Saint-Germain, Angel Di Maria, Football, Ligue 1, PSG, France