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The Bergamo outfit picked up a huge victory over the Serie A league leaders, with Cristian Romero, Josip Ilicic and Duvan Zapata all on the scoresheet.
Ibrahimovic hit headlines after he engaged in some beef with Zapata and told him, "I have scored more goals than you have played in your career".
That prompted former Middlesbrough midfielder De Roon to go after the 39-year-old Swede with a hilarious video on Twitter.
The comedic clip starts with footage of very moment Ibrahimovic insulted Zapata, followed by all three goals set to some hilarious music.
The Dutchman posted the video on Monday evening, two days after the huge result in Milan, and it's quickly going viral.
Could it come back to bite De Roon, though? Milan play Atalanta on the final day of the season at the end of May and could well be lifting the Scudetto if all goes well.
The Rossoneri are currently two points clear of rivals Inter at the top of the table, and seven ahead of regular champions Juventus - who are level on points with fifth-placed Atalanta on 36 points with a game in hand.
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