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United advanced to the FA Cup fourth round thanks to Scott McTominay's first-half header but it was far from a vintage performance.
The home side were second-best for most of the contest and Rashford looked off the pace for the entire game.
Rashford has three goals all season, hasn't scored since October and he didn't look like netting at all on Monday evening.
He started on the left wing and rarely threatened Matty Cash on the flanks, attempting a number of tricks.
One particular incident in the second half saw Mason Greenwood take a shot which Emiliano Martinez fumbled.
Rashford bizarrely opted to not chase the ball and let Martinez collect it without pressure.
The 24-year-old was replaced with five minutes to go by Anthony Elanga and he cut a forlorn figure while taking his seat on the bench.
Fans have reacted to Rashford's performance and they're worried about his drop off in performances.
One commented: "This is why you shouldn't play through injuries."
Another added: "I'd have him sat down with a sports psychologist instead of training at the moment."
third put: "Has been like this for his last few games. No energy, enthusiasm and interest."
While another said: "Rashford looks a completely different player right now."
Interim manager Ralf Rangnick was asked about Rashford's form post-match and he admitted he was unsure what was wrong.
He explained to Sky Sports: "Actually I don't know. I think he's trying hard. In training he was doing well in the last couple of days, that's why he was quite rightly in the starting XI.
"I think in the first half we found him quite often, but we also tried to get him into the box. In the second half that was not that often the case and that's why at the end of the game I decided to make two changes with Anthony Elanga and Jesse Lingard.
"It was very important to progress into the next round. Yes [confidence is important] especially for strikers - it's important that they score goals on and off, that there are moments of success.
"Of course it would be good, for example, for Marcus if he could score a goal but as long as he's trying, as long as he's training well I don't see that much of a problem."
United face Villa again in the Premier League on Saturday at Villa Park, while their fourth round FA Cup clash will be against Middlesbrough.
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