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The Red Devils significantly strengthened their squad in the summer with their stunning acquisitions of Raphael Varane, Jadon Sancho and Cristiano Ronaldo.
Ole Gunnar Solskjaer led his side to a second-place finish in the Premier League last season, but also fell short of capturing his first piece of major silverware as United boss after their Europa League final defeat.
However, Souness believes that there are “still more question marks” around United compared with the three favourites to win the Premier League title.
“I agree this is the strongest top four we’ve seen in the Premier League for several years,” he wrote for The Times.
“But with the caveat that there are still more question marks against Manchester United than any of the other title contenders -- Chelsea, Liverpool and Manchester City.
“United have not won any major trophies recently and have spent a great deal of money. Liverpool and City have been the real deal for the past few years and Chelsea have won the Champions League.
“If you put it like that, it’s common sense. The other ones have not only won trophies, but the big trophies, the important ones.”
Defending Premier League champions Manchester City dropped points against both Tottenham and Southampton in their opening five league matches.
Liverpool climbed to the top of the Premier League table on Saturday with their 3-0 win over Crystal Palace at Anfield.
Chelsea are considered a strong contender to dethrone City as English champions after the return of Romelu Lukaku from Inter Milan.
Liverpool hero Souness believes Thomas Tuchel’s Chelsea side will present a tough challenge for any of the other teams in the Premier League’s top four.
“If you’re playing against Chelsea, it’s hard to see where you’ll get joy,” he added.
“They can take you on in a football match or stand up to you physically. They have strength in the middle and on the flanks and now carry a real goal threat -- which they lacked last season -- after signing Romelu Lukaku.
“Like all the best teams, Chelsea have a plan B. If circumstances conspire against them, they can change their strategy.
“How well did they do that after going down to ten men away to Liverpool? Sometimes, for whatever reason, an obvious one being a red card, you have to adapt and plan B comes out, and they applied it perfectly.”
Featured Image Credit: PA
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