Igor Tudor has left Spurs by mutual consent after seven games in charge, the club has announced.
The Croatian, who was appointed last month to replace Thomas Frank, took just one point from his five Premier League matches.
He also oversaw a 7-5 aggregate defeat to Atletico Madrid in the Champions League last 16 stage, with Spurs winning the second leg 3-2 at home.
His last game in charge was last Sunday's 3-0 home loss to Nottingham Forest, which leaves Spurs just one point and one place above the Premier League relegation zone.
Advert
The club have released a statement confirming that Tudor, goalkeeping coach Tomislav Rogic and physical coach Riccardo Ragnacci have all left their roles by mutual consent.
"We thank Igor, Tomislav and Riccardo for their efforts during the past six weeks, in which they worked tirelessly," the statement reads.
"We also acknowledge the bereavement that Igor has recently suffered and send our support to him and his family at this difficult time.
"An update on a new Head Coach will be provided in due course."
As per Oddschecker, Sean Dyche and Roberto De Zerbi are joint odds-on favourites to replace Tudor at the Tottenham Hotspur Stadium.
Dyche and De Zerbi are both priced at 6/4 by BetVictor, with Fulham boss Marco Silva also a contender at 7/2.
Former Monaco manager Adi Hutter, who was linked with the role in the event of Tudor's departure earlier this week, is back at 6/1.
Ex-Spurs midfielder, academy graduate and coach Ryan Mason, who is unemployed after being sacked by Championship side West Brom in January, is at 10/1.
Mauricio Pochettino is also priced at 10/1, though his role with the United States men's national team ahead of the 2026 World Cup would rule him out of a return before the summer.
And former Spurs manager Harry Redknapp is priced at 20/1, with the 79-year-old having refused to rule out a return to the club if he was offered it.
Dyche, who has been out of work since his departure from Nottingham Forest in February, also hasn't distanced himself from the role - even if he didn't exactly give an answer either way.
During an appearance on talkSPORT on Saturday, the former Burnley boss said: "No matter what you do, it's a very tricky situation [as a manager being linked with a job].
"When you're the manager, you know you're going to get asked these [questions] at some point, whatever part of your career, if you're doing alright.
"And you get asked, and then you try and be respectful. Because obviously, let's use Tottenham as an example - brilliant club, massive club and all the rest.
"And then you go, 'Yeah, I'm flattered'. And then they go: 'Oh, he hasn't said no!'
"Then you go, 'No'. And they go: 'Oh, he wants it really?' And you say, 'Yes'."
Next Spurs manager odds
(via BetVictor - to take charge before May 30)
Sean Dyche (Unattached) - 6/4
Roberto De Zerbi (Unattached) - 6/4
Marco Silva (Fulham) - 7/2
Adi Hutter (Unattached) - 6/1
Ryan Mason (Unattached) - 10/1
Mauricio Pochettino (United States) - 10/1
Robbie Keane (Ferencvaros) - 14/1
Harry Redknapp (Unattached) - 20/1
Topics: Tottenham Hotspur, Football, Premier League
Ryan Smart