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Manchester City were dealt an injury blow when Aymeric Laporte was taken off on a stretcher against Brighton.
The French defender was down on the deck clutching his knee for a few minutes during the first half at the Etihad and was unable to continue.
He was replaced by Fernandinho in the 37th minute and carried off by medical staff.
Laporte had just earned a call-up to the France squad for the Euro 2020 qualifiers against Albania and Andorra this week.
His last international call-up was in March 2017 when he didn't feature in a friendly against Spain, and he was set to play for Les Bleus this week.
The 25-year-old has yet to make his international debut and was hoping to do so against Albania next Saturday.
But Laporte looked in a lot of discomfort and could be set for a spell on the sidelines in a blow for Pep Guardiola's men.
The Premier League champions have just Nicolas Otamendi fit at centre back after letting Vincent Kompany leave this summer.
John Stones has missed the last two matches with a thigh injury and was left out of England's squad by Gareth Southgate this week.
Manchester City went on to beat Brighton 4-0 on Saturday.
Kevin de Bruyne converted David Silva's cross in just the second minute to give them a flying start before Sergio Aguero doubled their lead before the break.
City's Argentine striker found the back of the net again in the second-half with substitute Bernardo Silva also getting on the score-sheet.
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