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Essentially, anything but a victory against a struggling Granada outfit would be a massive blow for the Catalans.
Interestingly, Granada claimed a famous win at Camp Nou at the end of last season, a result which all but ended Barca's title hopes.
Ahead of the game, our tipster takes a look at some of the best bets from Barcelona vs Granada to get your teeth stuck into.
Barcelona are 2/9 to win, with Granada priced at 11/1 to come away with the victory. A draw is priced at 5/1.
Prediction: 2-1 (7/1)
Match Result and Both Teams To Score: Barcelona and Yes (7/4)
Barcelona's defensive issues were exposed in the 3-0 defeat to Bayern and, at the moment, it feels like any team are able to hurt them when attacking.
The Catalans are yet to keep a clean sheet this season, while they have only recorded three clean sheets in their last 15 La Liga games - and two of those came against teams that were relegated last term in Eibar and Valladolid.
To Win Both Halves: Barcelona (7/4)
It has been a poor start to the season for Granada, who are still seeking their first win after four matches.
They began the season with back-to-back draws against Villarreal and Valencia, but have now lost their last two matches and we reckon their misery will continue, too, especially with Barca needing to bounce back after defeat in the Champions League.
First Goalscorer: Memphis Depay (14/5)
Barcelona’s two La Liga wins this season have come at the Camp Nou, including a 2-1 victory over Getafe last time out.
Another positive for Barca is in the form of summer signing Memphis Depay, who has scored two goals in his first three appearances.
Odds are correct at the time of publication and are, as always, subject to change.
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Neyder Lozano remains on the sidelines with a long-term leg injury, but the visitors are otherwise in excellent shape in terms of their squad.
It would not be a surprise to see head coach Moreno switch to a three-man defence at Camp Nou, with Luis Suarez and Darwin Machis operating as the front two.
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