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The 34-year-old former WBC champ boasted that he could have destroyed the boxing legend if they had met in the squared circle.
But Lennox Lewis brutally slammed Wilder for bragging about the idea of knocking out a younger Tyson.
When KO artist Wilder was asked about the Brit boxing legend's response, he explained why Tyson wouldn't stand a chance against him.
"My hand speed, I'm too long, I'm too tall, my athleticism, my feetwork, all that gives me an advantage, it plays a big part," the 'Bronze Bomber' told EsNews.
"No disrespect to Mike Tyson, in his era he was the best but this is a new era.
"No old-school fighter should beat a new-school fighter. Look at the technology we have.
"Nobody has a natural killer instinct as I do, ain't anybody could ever knock me out. I'm very confident in what I say and I speak what I do."
Wilder told TMZ in his 2018 interview that he would "kick the hell" of a prime 'Iron' Mike, who is widely revered as one of the most feared punchers in history.
The 'Bronze Bomber' explained: "Me vs Tyson in '86, I'd kick the hell outta that guy.
"Listen, I've got to keep it real. I know people always go back to the old school or look at the new school and there's no school where I'm not No 1 on Earth."
Tyson initially responded to Wilder's claim in 2018 by dismissing his prediction for the fight between the two destructive punchers.
However, the 54-year-old boxing legend has since broken his silence and properly responded to Wilder over his comments.
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