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Fans have previously debated what would happen if the 34-year-old American star clashed with a prime 'Iron' Mike in a fantasy fight.
Boxing Fight Simulations has now put the fight into action on Fight Night Champion, but the YouTuber has played it out as a bare-knuckle boxing match instead.
Both Tyson and Wilder, who are widely revered for their devastating knockout abilities, wasted no time in throwing powerful shots at one another from the opening bell.
But the 'Bronze Bomber' made the early breakthrough and caught Tyson with a right hook as the boxing legend went on the offensive.
Tyson managed to beat the 10 count and both fighters returned to their respective corners, with Wilder also taking a fair bit of damage from the 'Baddest Man on the Planet.'
Former WBC champ Wilder caused more trouble for Tyson deeper into the fight after connecting with a powerful right.
However, 'Iron' Mike was able to recover from the setback and continued to take the fight to the KO artist.
Wilder would once again assert his dominance over the boxing legend by knocking him down for the third time in the fight.
The 'Baddest Man on the Planet' made it back to his feet at the nine count and fought on, but Wilder sealed the victory after their corner rests.
The 'Bronze Bomber' connected with a right on Tyson in the centre of the ring and sent him crashing to the canvas.
Wilder, who suffered his first defeat to Tyson Fury back in February, previously argued that he would have beaten a prime 'Iron' Mike in a fight.
And Tyson has since responded to his fellow American's bold claim and admired his confidence in suggesting such a comment.
Featured Image Credit: PA/EA Sports
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