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McGregor, 31, shocked MMA fans around the world on Sunday when he took to social media to announce that he was done with fighting.
McGregor, who has already outlined the real reasons for his retirement, took to Instagram on Sunday and posted a photo of his 'retirement' cake.
Mayweather called out the 'Notorious' for "quitting" and referenced boxing legend Mike Tyson's claim that McGregor could have beaten him in a rematch.
'Money' wrote in the comments: "If I'm not mistaken, didn't you tell Mike Tyson you could beat me if we fought a second time? Now you're quitting!
"I thought you wanted to beat the best? Well, if you decide to come back, I will be waiting to punish you again."
McGregor responded to Tyson's praise last month and vowed to "crack the puzzle" and "beat" Mayweather in a lucrative potential rematch.
Mayweather, who retired in 2017 with an undefeated 50-0 record, secured a 10th-round TKO victory over McGregor in their boxing super-fight.
The former five-division world champ teased fans in February that he was open to the idea of a rematch and would 'whip his a**e' in another fight.
Mayweather has since continued to take shots at McGregor and even called him out during a training session in April.
UFC president Dana White has said that he would welcome McGregor's retirement, despite claiming he would miss him should he never choose to fight again.
Featured Image Credit: PA
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