And ahead of their massive lightweight showdown, the UFC have released a spine-tingling promo that will get you pumped for the event.
The video chronicles the spectacular rise of McGregor and highlights his stunning victory over Poirier at UFC 178 back in September 2014.
It then cuts to Poirier who exclaims: "You can have all the money in the world, but you can't buy heart!"
It then showcases the American's remarkable career resurrection and his own emphatic victory over McGregor at UFC 257 in January.
Check out the trailer below with the promotion billing McGregor vs. Poirier 3 as the 'biggest PPV of the year'.
The winner of McGregor vs. Poirier is poised to earn a shot at UFC lightweight king Charles Oliveira.
'The Nigerian Nightmare' recently spoke about the difficult life McGregor leads.
Speaking on the True Geordie Podcast, he said: "My daddy used to always say, 'Everybody loves the chair, but while they're chairing they can't make the move.'
"That's exactly what Conor feels like and I know it - it's tough. I know it's hard being Conor, I know it's hard. I am a champion and I know how hard it is to be the champion now.
"I can't imagine what Conor's going through, that's got to be hard because you can't do anything - people can't wait to move because now people are just waiting to rub it in your face."
Usman added: "Of course you've got the money, you've got all this, you've got all that, but bro, you got knocked out in your last fight.
"And then you've [won] one in your last four or five fights, something like that - people can't wait to throw that in your face.
"So yeah, it's a tough life to lead."
Featured Image Credit: UFC
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