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With 4 minutes and 29 seconds on the clock in the second round, the Czech Republic fighter put Reyes away with a vicious spinning elbow while he was against the cage.
Reyes landed horrendously on his head as he hit the canvas at a sickening impact, with the bout immediately waved off by referee Herb Dean.
UFC president Dana White shared another angle of the stoppage and it looks even more brutal.
Reyes was motionless for a brief period before eventually sitting up, with Prochazka checking to see how he was.
Prochazka is now on an insane streak of 10 straight knockouts. In nine years in MMA, he's knocked out 25 of his 28 opponents and many are now tipping him to challenge for the light heavyweight title in the near future.
Last night, he collected an extra $100,000 on his pay packet courtesy of 'Performance of the Night' and 'Fight of the Night' bonuses.
"It was a very nice fight," Prochazka said post-fight, as per MMA Fighting.
"I just want to show the beauty of the art but sometimes I go very quickly for the win. By that, I catch some punches. I'm learning still from fight to fight.
"I just flow. After some counter punches from Dominick, I can have no chance to think for some plans. I just was in the flow. After that, the spinning elbow, let's try it."
As for Reyes, fans will remember ran Jon Jones, one of the best to ever do it, extremely close in their light heavyweight title fight at UFC 247 before 'Bones' was given the decision win.
But 'The Devastator' has now lost three consecutive fights and it's hard to see where he goes from.
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