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The Notorious returned to the octagon on Saturday night after a year of inactivity, and his usual retirement, only to lose in spectacular fashion to Poirier.
Ahead of the fight the Irishman had been talking up his return to action and making it sound like he was ready to be far more active in UFC.
Even after the loss McGregor pointed to his inactivity as a possible reason for the loss, without making excuses, suggesting he was ready to get back in the octagon as soon as possible.
However that might now be delayed with the former two weight champion being given a medical suspension up to six months.
McGregor can have no contact for 30 days due to the TKO, he can't compete for a minimum of 45 days and he must get clearance on an X-ray of his right tibia and fibula or it's no contest for 180 days.
Whilst he might not be able to participate in contact, it hasn't stopped the Irishman returning to training straight away, with the 32-year-old working out just 24 hours after being stopped for the first time in his career.
The rest of the competitors from UFC 257 have also been handed their medical suspensions with Poirier only needing to wait seven days, the mandatory rest period, though he's unlikely to be in a hurry to return to action.
The Diamond was number two in the rankings going into Fight Island, behind Justin Gaethje, and his performance has made him a likely contender for the lightweight title.
Khabib Nurmagomedov still holds the belt but is currently retired and it looks unlikely he will return to action anytime soon.
Former two time opponent for McGregor, Nate Diaz, has put his name forward to fight Poirier next, calling the 32-year-old out on social media.
Michael Chandler, who won the co-main event, must also wait seven days following his impressive debut against Dan Hooker.
The New Zealander, who had also lost to Poirier on his previous appearance, has the same 45 days for the TKO as McGregor and 30 days of no contact.
It'll be interesting to see how the lightweight division shakes out from here and when we'll next see McGregor inside the octagon.