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YouTube channel Janoskians uploaded the video in 2015 and said that Tate offered them "two minutes each to 'see how many times she can make us tap.'"
And the 34-year-old former women's bantamweight champ outclassed all four men inside the octagon.
Tate locked in several deadly submission holds on her opponents, including a standing chokehold where she incredibly lifted a YouTuber off his feet.
One of the other YouTubers told his pals that he "knows I'm f****d right now" as Tate had him pinned to the octagon mat.
Another YouTuber hilariously ran around the octagon as he tried to last out all two minutes against Tate.
Some fight fans have flocked to the comments to reveal that they wouldn't want the opportunity to fight against Tate.
YouTube user Kevin Wendal Crumb posted: "I couldn't do this. I'd be erect the moment she clinched me. That's just how my body would react to it."
While another fan wrote: "Misha has amazing technique."
Arnold May II said: "Whenever armchair mixed martial artist say 'I can take that chick in the octagon,' they should just watch this video."
A fourth added: "She doesn't even look tired despite the fact she fought all of you and you guys can't even breath."
Tate, who fought against the likes of Ronda Rousey, Holly Holm and Amanda Nunes, has since retired from MMA.
Her last fight came in 2016 against Raquel Pennington at UFC 205 and she lost on decision.
UFC president Dana White has credited Tate for helping to drive the women's division forward after her clash with Rousey in 2013.
He explained: "But what changed me and what I think changed a lot of people about women's MMA was Tate vs Rousey.
"That was a fight worthy of a men's fight: two incredibly talented women who are very well-rounded, and it doesn't hurt when they're beautiful, too."
Featured Image Credit: YouTube
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