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McGregor returned to action for the first time in just over a year at UFC 257 to take on Dustin Poirier, unlike his previous return, last year's win over Donald Cerrone, it was McGregor who was defeated.
The former two weight champion's demeanour inside and outside the octagon doesn't always win him fans, although it's also part of his allure, and rivals like Khabib Nurmagomedov and Jake Paul were quick to comment on the loss.
Now Mayweather has joined in on the pile on. Posting on Instagram, in reply to a question about why McGregor is loved but Mayweather isn't, the retired boxer went in on his former opponent.
"I seen this post and my take on it is that the world knows Con Artist McLoser can steal everything from me and be loved but I'm hated," the undefeated boxer posted, "That just lets you all know that racism still exist.
"Just know, that bum will never be me or be on my level. I'm just built different, my mindset is on another planet, my skills are second to none, I'm a natural born winner and yes I talk a lot of trash, but every time I back it up!
"This is what they hate. It's sad that you can be a poor black kid from the ghetto that has dealt with racism your whole life and work extremely hard to put yourself and your family in a better position, and most of the hate come from my own people.
"Connor cannot even win in his own sport, but talking about coming back to boxing to fight Pacquiao. Nobody wants to see that, it's like my leftovers eating leftovers."
McGregor, who lost to Mayweather in 2017, had been linked with a potential return to boxing to fight Manny Pacquiao, with the Filipino stoking the flames of the rumours with a pre fight tweet.
Jake Paul is also hoping to get the former UFC lightweight champion in the ring at some point, having previously boxed against a YouTuber and a former NBA player.
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