The tie of the night sees Chelsea travel to Liverpool, while fellow Premier League clubs Tottenham and Watford clash at Stadium MK for a place in the next round draw.
Liverpool have a 100% record this season winning all six of their Premier League fixtures as well as their Champions League opener against PSG.
However, Chelsea are in good form too, winning five and drawing one of their six league fixtures so far. The London club also won their first UEFA Europa League game 1-0 away to PAOK.
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Both sides are expected to make changes, with Liverpool boss Klopp confirming Simon Mignolet will replace Alisson Becker between the sticks. Striker Dominic Solanke could also return for the Reds to face his former side, whilst Adam Lallana and Divock Origi will both miss out due to injury.
Davide Zappacosta, Andreas Christensen, Ross Barkley and Alvaro Morata are all rumoured to start as Sarri is expected to switch things up following their bore draw away to West Ham.
Klopp's men are favourites at 10/11, while Sarri's Chelsea are 11/4. Two of the last three meetings between the sides have ended in 1-1 draws, while Chelsea won the other 1-0. A draw in the clash tonight is priced at 14/5 and under 2.5 goals is 6/5.
Former Chelsea striker Daniel Sturridge is evens to find the net at any time in the game and fellow ex-Blues forward Solanke is 6/4.
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Out of form Morata and World Cup semi-finalist Eden Hazard are 17/10 to bag a goal for Chelsea at any time.
Spurs and Watford will play their fixture at Stadium MK as Tottenham's new stadium is not ready yet and Wembley is unavailable.
Mauricio Pochettino's men are heavy favourites at 4/9 while the Hornets are outsiders at 5/1.
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The Argentine manager is expected to make changes tonight as his side make the 50-mile trip to Milton Keynes, Pochettino said: "We have a lot of games ahead. I think we rotate, trying to find the best solution to try and win games."
Watford are also rumoured to be fielding a weakened side, as captain Troy Deeney is unavailable due to a broken nose, Gerard Deulofeu, Sebastian Prodl, Stefano Okaka and Miguel Britos will also miss out due to injuries.
The Hornets might be worth a punt at 5/1 as they currently sit one place above Spurs in the Premier League table and have already beat them 2-1 this season. Watford to win and both teams to score is 8/1, while a repeat of the earlier score line is 16/1.
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See the remainder of tonight's fixtures below:
Arsenal (1/3) vs Brentford (7/1)
Nottingham Forest (6/4) vs Stoke City (9/5)
West Ham United (1/11) vs Macclesfield Town (18/1)
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