West Ham host Manchester United at the London Stadium in the early kick-off, while Chelsea face Liverpool at Stamford Bridge at 17:30.
Elsewhere, Arsenal vs Watford, Everton vs Fulham, Huddersfield vs Tottenham, Manchester City vs Brighton, Newcastle vs Leicester and Wolves vs Southampton all kick off at three.
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Cardiff vs Burnley is the only Premier League fixture on Sunday.
The Hammers are unbeaten in their last three, beating Everton and Macclesfield while holding Chelsea to a draw at home.
However, Manuel Pellegrini's side are only one place above the relegation zone making them 7/2 underdogs.
Jose Mourinho's United (6/7) suffered a shock exit from the Carabao Cup during the week to Frank Lampard's Derby County and failed to beat newly promoted Wolves at Old Trafford last weekend.
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Under pressure Mourinho can't afford anything other than a win this weekend if he fails to leave London without all three points his job may be at serious risk. You can back the Portuguese manager to lose his job by the end of the weekend at a nice 16/1.
Chelsea knocked Liverpool out of the EFL League Cup midweek at Anfield as Emerson and Eden Hazard scored for the Blues as they came from behind to win 2-1.
However, the Reds are 6/4 favourites to scoop all three points at the Bridge tomorrow evening, and with the likes of Allison Becker, Mo Salah and Robert Firmino expected to return to the starting line-up, rightly so.
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The West London side are 9/5 to beat Liverpool for the second time this week, while a repeat of the scoreline is 17/2.
In-form Hazard is 13/8 to score any time for his side and Mo Salah is 6/5 to find the net for only the fourth time this season after he banged them in for fun last term.
Title holders Man City are 1/12 to beat struggling Brighton, while the Seagulls are a massive 30/1 to cause an upset at the Etihad.
Tottenham are 4/9 to beat bottom of the table Huddersfield, but they might be worth a punt at 6/5 to win -1 goal.
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David Wagner's men are 13/2 to be the third side to beat Spurs this season in the league.
Arsenal are also 4/9 to pick up three points at the Emirates on Saturday, while Watford might be worth backing at 6/1.
The Hornets are two places above the Gunners in the league after winning four of their opening six games, including a victory against Man United.
Latest betting odds for the remaining fixtures:
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Everton (3/4) vs Fulham (15/4)
Newcastle (8/5) vs Leicester (2/1)
Wolves (4/5) vs Southampton (17/4)
Cardiff (13/8) vs Burnley (11/5)