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Incredibly, Ronaldo has scored a staggering 134 goals in the tournament - the most ever. Will Young Boys have what it takes to be able to keep him at bay for 90 minutes?
Ahead of the game, our tipster Robert Mann takes a look at some of the best bets from Young Boys vs Manchester United to get your teeth stuck into.
Young Boys are 15/2 to win, with Manchester United priced at 1/3 to come away with the victory. A draw is priced at 17/4.
Prediction: 0-3 (17/2)
Half-Time/Full-Time: Manchester United/Manchester United (1/1)
United head into this game with some serious momentum behind them and they should be too hot for the Swiss outfit to handle.
On the face of it, it's hard to escape the possibility that this could be a bit of a mismatch, assuming Ole Gunnar Solskjaer picks his strongest team, of course.
First Goalscorer: Cristiano Ronaldo (12/5)
When it comes to European football and scoring goals, look no further than the man himself, Ronaldo.
The five-time Ballon d'Or winner, who scored twice on his second debut against Newcastle on Saturday, was part of the last United side to win the Champions League back in 2008 and went on to win the competition on a further four occasions with Real Madrid.
Win to Nil: Manchester United (11/8)
Young Boys have only won two out of their five matches in the Swiss Super League which can only bolster United's chances of three points here.
Having said that, though, the Swiss outfit can tend to be quite entertaining to watch, but at the expense of conceding goals - having kept just three clean sheets in their last 12 fixtures.
Odds are correct at the time of publication and are, as always, subject to change.
Please gamble responsibly. For more information visit: https://www.begambleaware.org.
Young Boys will again be without the services of Fabian Lustenberger and Jean-Pierre Nsame on Tuesday due to injuries, while Joel Monteiro, Esteban Petignat and Nico Maier will also be absent.
The Swiss outfit are expected to line up in a 4-4-2 formation, with Meschack Elia being joined in the final third by Theoson-Jordan Siebatcheu.
Edinson Cavani also missed that match with a knock and Solskjaer must decide whether to hand Ronaldo another start or save him minutes.