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But after travelling to Portugal to take on Pacos de Ferreira in Europe's third-tier competition just days later, Spurs were stunned in a 1-0 defeat after Espirito Santo fielded a shadow side.
But this tie is far from over and Spurs are likely to see big names return to the starting line-up - including the likes of Harry Kane.
Ahead of the game, our tipster Robert Mann takes a look at some of the best bets from Tottenham Hotspur vs Pacos de Ferreira to get your teeth stuck into.
Tottenham Hotspur are 1/9 to win, with Pacos de Ferreira priced at 16/1 to come away with the victory. A draw is priced at 6/1.
Prediction: 4-0 (7/1)
Team Most Booking Points: Pacos de Ferreira (4/5)
Last week's first leg was a fiery occasion, with six yellow cards dished out in total.
We reckon that the Portuguese side to receive the most booking points is a certainty this evening, especially given Spurs' electric pace going forward.
To Score 4+ Goals: Tottenham Hotspur (7/4)
Pacos de Ferreira's triumph in the first leg is not in keeping with their other results in recent weeks, having only scored twice in 270 minutes of football.
Expect Espirito Santo to call on a few key men to steady the ship and get an early goal, including Kane following his decision to stay at the club this season.
First Goalscorer: Harry Kane (15/8)
The Kane transfer saga has, as you can imagine, cast a shadow over the north London club, but the 28-year-old has since revealed that he will be staying at Spurs - for the time being, anyway.
Espirito Santo may also take the opportunity to hand him his first start this campaign, with the England international well behind the rest of the group in terms of fitness.
Odds are correct at the time of publication and are, as always, subject to change. Please gamble responsibly. For more information visit: https://www.begambleaware.org.
New signing and defensive stalwart Cristian Romero could also feature in the heart of defence as the club has confirmed he has recovered from a minor injury which kept him out of the squad on Sunday.
Helder and Lucas Silva are in line to return for Pacos de Ferreira after the two wide players dropped out of the side for last weekend's game against Estoril.
Elsewhere, Matchoi Djalo is pushing for a start, having only been named as a substitute for the last two fixtures.
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