Harry Maguire and Aaron Wan-Bissaka make their debuts for Manchester United against Chelsea on Sunday afternoon.
The £130 million defensive duo were named in Ole Gunnar Solskjaer's first side of the season for the clash at Old Trafford.
They were joined by Victor Lindelof and Luke Shaw at the back with Paul Pogba, Scott McTominay and Andreas Pereira making up the three-man midfield.
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Jesse Lingard, Anthony Martial and Marcus Rashford started up front for the Red Devils.
In terms of injuries, Eric Bailly and Timothy Fosu-Mensah are both sidelined and will not take part against Chelsea.
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Solskjaer also revealed Alexis Sanchez would not be ready to feature this weekend, despite training well after sustaining an injury with Chile at the Copa America this summer.
"Alexis has come in and trained well." he said via Manchester United's official website.
"Of course, he's four or five weeks behind the boys and he's not played apart from a one behind-closed-doors [friendly] here, so I think he'll see this as an opportunity, as well, to make his mark."
Chelsea manager Frank Lampard named Mason Mount and Tammy Abraham in his side for the Premier League opener at Old Trafford.
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N'Golo Kante missed Sunday's clash against Manchester United, while Willian failed a late fitness test.
Cesar Azpilicueta was joined in defence by Andreas Christensen, Kurt Zouma and Emerson while Mount was named in midfield alongside Mateo Kovacic and Jorginho.
Abraham was joined by Ross Barkley and Pedro up top for the Blues.
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