Ole Gunnar Solskjaer's Manchester United will face FC Astana, FC Partizan and AZ Alkmaar in the 2019/20 Europa League group stage.
The club must travel over 5,688 miles in the competition as they fly to Kazakhstan, Serbia and Holland.
In terms of Premier League sides, Arsenal have one of the toughest draws in the competition and will play Eintracht Frankfurt, Standard Liege and Vitoria SC.
Wolves will travel to Turkey to face Super Lig giants Besiktas, while fixtures against SC Braga and Slovan Bratislava will likely prove difficult for Nuno Espirito Santo's side.
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Scottish Premiership sides Celtic and Rangers also face tough tests against the likes of Lazio and FC Porto.
Here is the draw in full:
GROUP A: Sevilla, APOEL, Qarabag FK, F91 Dudelange
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GROUP B: Dynamo Kyiv, FC Kopenhavn, Malmo FF, FC Lugano
GROUP C: FC Basel, FC Krasnodor, Getafe, Trabzonspor AS
GROUP D: Sporting CP, PSV Eindhoven, Rosenborg, LASK
GROUP E: Lazio, Celtic, Stade Rennais, Cluj
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GROUP F: Arsenal, Eintracht Frankfurt, Standard Liege, Vitoria SC
GROUP G: FC Porto, Young Boys, Feyernoord, Rangers
GROUP H: CSKA Moscow, Ludogorets, Espanyol, Ferencvarosi
GROUP I: Wolfsburg, Gent, Saint Etienne, FC Olexandriya
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GROUP J: AS Roma, Borussia Monchengladbach, Istanbul Basaksehir, Wolfsberger
GROUP K: Besiktas, SC Braga, Wolverhampton Wanderers, Slovan Bratislava
GROUP L: Manchester United, FC Astana, FC Partizan, AZ Alkmaar
Europe League match day one will begin on Thursday 19th September.
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There will be two rounds of fixtures in October, two in November and the final round on December 10/11.
The 202 Europa League final will take place at The Stadion Energa Gdańsk in Gdańsk, Poland on Wednesday, 27 May.
What are the stand out fixtures from Friday afternoon's 2019/20 Europa League group stage draw?
Let us know your thoughts in the comments below.
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