Mark Warburton's Super Hoops have made a good start to life in the Championship this season, but they have suffered back-to-back defeats in their last two outings against Bristol City and Bournemouth.
Meanwhile, Rafael Benitez has enjoyed an excellent start to his time as Toffees manager in the Premier League, but that came to a crashing end on Saturday night as they were beaten comprehensively by Aston Villa.
Both sides haven't met for six years when they were both in the top flight, with Everton leaving victorious, but can QPR change that form this evening?
Ahead of the game, our tipster Robert Mann takes a look at some of the best bets from Queens Park Rangers vs Everton to get your teeth stuck into.
Queens Park Rangers vs Everton betting tips & predictions
Queens Park Rangers are 16/5 to win, with Everton priced at 3/4 to come away with the victory. A draw is priced at 11/4.
Prediction: 3-2 (40/1)
Full-Time Result and Both Teams To Score: Queens Park Rangers and Yes (13/2)
Everton have won the last four meetings and QPR haven't defeated Everton in London since 1996, however, tonight will be their greatest opportunity to buck that trend.
So far this season, QPR have scored in every game they have played and the Super Hoops will be aiming to make it 11-in-a-row against the Merseyside outfit.
First Goalscorer: Lyon Dykes (6/1)
In order to have the best chance of sealing their name into the draw for the next round, QPR may need to turn to forward Lyndon Dykes for inspiration.
The Scotland striker has been in fine form for his country and even netted in the last round of the Carabao Cup, too.
Under/Over Goals: Over 3.5 Goals (7/4)
These two teams have a long history when it comes to previous head-to-head encounters.
Five out of the last six meetings between the two sides ended either with both teams scoring or three goals plus, which makes tonight’s game almost a certainty to rain goals.
Odds are correct at the time of publication and are, as always, subject to change.
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Queens Park Rangers team news
Sam Field and Lee Wallace are Warburton's only injury concerns for the welcome of Everton.
Everton team news
Benitez, meanwhile, has five confirmed absentees for the trip to Loftus Road.