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Said Benrahma opened the scoring for West Ham at the London Stadium before Cristiano Ronaldo cancelled out his opener five minutes later.
Jesse Lingard broke the deadlock late in the second half with a stunning curling strike past Lukasz Fabianski into the top-right corner.
However, Solskjaer was furious after VAR ruled that Luke Shaw had handballed in the box late in injury time.
Referee Martin Atkinson reviewed the footage on his pitch-side monitor before he pointed to the spot, with Solskjaer picking up a water bottle before slamming it on the touchline.
United fans flocked to social media to share their reactions to Solskjaer’s surprising reaction, which was broadcasted on Sunday’s Match of the Day 2.
Solskjaer’s reaction may evoke memories of Mourinho’s touchline celebration during his spell at United manager.
Marouane Fellaini scored a dramatic injury-time winner against Young Boys in United’s Champions League clash in 2018 and ensured their place in the last 16.
Mourinho was spotted slamming a set of pitchside water bottles on the Old Trafford touchline in a moment of relief for the then-United manager.
West Ham boss David Moyes brought off Jarrod Bowen and Mark Noble came on in injury time.
Noble surprisingly stepped up for the penalty and saw his crucial spot-kick effort denied by David de Gea.
Speaking after the 2-1 win at the London Stadium, Solskjaer staunchly defended Shaw and questioned the decision to award West Ham a penalty.
“Even though it's from half a yard away and it's clipped up, Luke probably makes himself bigger which is probably their reasoning for giving the penalty,” he told MUTV.
“It's one of them: do they want the defenders to just have their arms behind the back? You can't defend properly then, can you?
“I’ve seen Mark Noble score so many penalties and that’s the decision -- sometimes it goes for you, sometimes it goes against you.
“As I said last week, it’s always the outcome that determines the narrative. This time it turned out not to be the right call, but it’s just football.”
Featured Image Credit: Twitter/PA