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Former United manager Jose Mourinho signed the 39-year-old Swedish star in 2016 after Ibrahimovic left Paris Saint-Germain.
However, Here We Go Podcast host Francesco Porzio now reports that the former Sweden international will miss the first leg of Milan's Europa League clash with United.
According to reports, Ibrahimovic is suffering from a 'muscular injury' ahead of the United match.
Milan drew against Serbian side Red Star Belgrade in both legs of their round-of-32 Europa League matches, but they progressed through to the round of 16.
United, meanwhile, thrashed Real Sociedad 4-0 away before drawing 0-0 at Old Trafford in the return leg.
The return leg will be held at the San Siro on 18th March.
Ibrahimovic previously said that he made his harshest critics "eat their own words" after his impact at United and in the Premier League.
The former PSG and Inter Milan star explained: "I wasn't always sure that I would play in England, but when I took the decision that I would, I was very clear in my mind that there was only one team I would play for: United.
"Still, everybody was talking, thinking they knew everything.
"My challenge was, at the age I was, coming to England, where I had years of everybody was saying I wasn't good enough and all this bulls**t.
"I like those things because they trigger me. They give me adrenaline.
"After three months, all of them were eating their own words.
"I needed new haters because all the old ones became my new fans!"
Featured Image Credit: PA
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